Description: The Center for Interdisciplinary Cardiovascular Sciences (CICS; Director: Masanori Aikawa, MD, PhD) at the Brigham and Women’s Hospital (BWH), a Harvard-affiliated hospital, is seeking a postdoctoral research fellow to contribute to its bioinformatics program within the Proteomics Research Group (Director: Sasha Singh, PhD).
Responsibilities: We are seeking individuals to collaborate with biologists on three major endeavors: 1) Analysis of high dimensional data acquired from a multi-omics study that includes one or more of proteomics, metabolomics and transcriptomics for drug target discovery. 2) Posttranslational modification mapping and characterization. 3) Expanding on current targeted proteomics workflows and implementation of spectral libraries into peptide identification workflows. Additional projects that would interest the candidate include single-cell transcript profiling and systems biology/network analysis aimed to predict the beneficial and off-target effects of putative therapeutics. The successful candidate will be able to collaborate with a number of talented researchers, will guide them through their research endeavors and will be a co-author on publications arising from these projects.
Job Requirements: The candidate must have a PhD or equivalent experience. The candidate will help to expand a bioinformatics program for mass spectrometry-based target discovery platforms. Specific skill requirements include data analysis with statistics, script languages such as Python, programming languages such as C, C++, C# or JAVA, and scripting in Linux/UNIX. Experience with computational mass spectrometry analysis is preferred; however, basic knowledge of mass spectrometry or equivalent biochemistry will also be considered. Experience in systems biology and/or machine learning is also advantageous. We also expect an individual with outstanding motivation and a firm commitment to productivity.