As of the date of this posting, all plenary sessions have been identified and session co-chairs have been recruited. The chairs are currently extending invitations to potential invited speakers for inclusion in their sessions. A preliminary draft agenda of the Scientific Program including names and affiliations of confirmed co-session chairs is included below.
Satellite Meeting
Wednesday, April 2, 2014: 2-5 pm
Lerner Research Center (on the campus of the Cleveland Clinic) Room NE1-205
Requires separate registration
Program Title: “Stem Cells for Disease Modeling and Regenerative Therapeutics
Program Organizer: Marc S. Penn, MD, PhD – Summa Health System & Northeast Ohio Medical University
Invited Speakers:
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Keith March, MD, PhD – Indiana University School of Medicine
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Stan Gerson, MD – Case Western Reserve University
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Robert Deans, PhD – Exec VP Regenerative Medicine, Athersys, Inc. – Therapeutic response pathways and development of adult stem cells for CNS injury and disease
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Feng Dong, MD, PhD – Northeast Ohio Medical University - Stem cell strategies for post-AMI cardiac repair in diabetes
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Dan Simionescu, PhD – Clemson University - Bioengineering challenges in heart valve tissue regeneration
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Marc. S. Penn, MD, PhD – Summa Cardiovascular Institute, Summa Health System and Professor of Medicine and Integrative Medical Sciences at Northeast Ohio Medical University – Stem cell homing for tissue repair
ISACB Meeting Keynote Speaker
Friday, April 4, 2014
Speaker: Alexander W. Clowes, MD – V. Paul Gavora and Helen S. and John A. Shilling Endowed Chair of Vascular Surgery, Department of Surgery, University of Washington
Topic: Vein Graft Stenosis – Does it Have a Genetic Origin?
Plenary Sessions
Thursday, April 3, 2014 (8am) thru Saturday, April 5, 2014 (1pm)
Session I: Cardiovascular Mechanobiology
Co-sponsored by the Biomedical Engineering Society (BMES)
Session Co-chairs:
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David Vorp, PhD – University of Pittsburgh
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Elena Aikawa, MD, PhD – Brigham and Women’s Hospital; Harvard Medical School
Session Invited Speakers and Topics:
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David Merryman, PhD – Vanderbilt University – Mechanobiological mechanisms in calcific aortic valve disease
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Tina Rinker, PhD – University of Calgary – Nanoparticle interactions with the endothelium
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Steven A. Fisher, MD – University of Maryland Baltimore – Smooth muscle cell biology and mechanobiology
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Elena Aikawa, MD, PhD – Brigham and Women’s Hospital – Matrix vessels in cardiovascular calcification
Session Proffered Abstract Presentations:
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Joseph Chen – Vanderbilt University – The role of Notch1 mechanobiology in calcific aortic valve disease
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Samantha Ratley – University of Notre Dame – The role of bicuspid aortic valve hemodynamics in acute aortic dilation
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Meghan A. Bowler – Vanderbilt University – Dimethyl Celecoxib blocks cadherin-11 mechanotransduction and calcification of valvular fibroblasts
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Jason R. Cook – Icahn School of Medicine at Mount Sinai New York – Characterization of dilated cardiomyopathy in mice with Marfan Syndrome
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Frederick W. Damen – Purdue University – 4-dimensional ultrasound imaging of left-ventricular dynamics
Session II: Cardiovascular Biomaterials, Tissue Interactions and Pathobiology
Co-sponsored by the Society for Biomaterials (SFB)
Session Co-chairs:
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Howard Greisler, MD – Loyola University Stritch School of Medicine
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Nicholas P. Ziats, PhD – Case Western Reserve University
The session is designed to address the dichotomies of the effects of materials on biology and the effects of biology upon materials in the development of the next generation of more clinically efficacious cardiovascular biomaterials.
Session Invited Speakers and Topics:
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Paul DiCorleto, PhD – Cleveland Clinic – Role of inflammatory mechanisms in vascular biology and physiology
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Daniel I. Simon, MD – University Hospitals Case Medical Center – S100A9 in vascular inflammation and thrombosis
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Toshiharu Shinoka, MD, PhD – Nationwide Children’s Hospital – Current status of tissue engineered vascular grafts in pediatric cardiac surgery
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Mukesh Jain, MD – Case Cardiovascular Research Institute – Circadian Control of Vascular Disease
Session Proffered Abstract Presentations:
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Jun-ichiro Koga – Harvard Med School and Brigham and Women's Hospital – Macrophage notch signaling accelerates vein graft disease in Ldlr-/- mice
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Hiroshi Iwata – Brigham and Women's Hospital – Global proteomic analysis reveals Parp14 as a novel regulator of macrophage activation
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Julie A. Phillippi – University of Pittsburgh – Bicuspid aortic valve patients exhibit superoxide accumulation in the ascending aorta
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Dmitry O. Traktuev – Indiana University – Activin A is a key modulator of endothelial and adipose stromal cell interactions
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Dena C. Wiltz – Rice University – Presence of Ryanodine receptor isoforms 2 and 3 and the mineralization action of Lysophosphatidylcholine through the Ryanodine receptor in valvular interstitial cells
Session III: Novel Cardiovascular Diagnostics, Imaging and Therapeutics
Co-sponsored by the Society for Cardiovascular Pathology (SCVP)
Session Co-Chairs:
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Paul DiCorleto, PhD – Cleveland Clinic
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Daniel I. Simon, MD – University Hospitals Case Medical Center
Session Invited Speakers:
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Marc S. Penn, MD, PhD – Summa Cardiovascular Institute, Summa Health System and Professor of Medicine and Integrative Medical Sciences at Northeast Ohio Medical University – Multi-marker approach for cardiovascular risk assessment
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Saptarsi Haldar, MD – Case Cardiovascular Research Institute – Bromodomain inhibition in heart failure – placing BETS on Chromatin
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Farouc Jaffer, MD, PhD – Massachusetts General Hospital – Intravascular molecular imaging of inflammation and proteolyic activity in atherosclerosis
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Eric Brey, MD – Illinois Institute of Technology – Imaging Challenges in biomaterials and tissue engineering
Session Proffered Abstract Presentations:
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Sandeep Kumar – Emory University – Inhibition of mechanosensitive microrna-712 decreases endothelial inflammation and atherosclerosis
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Nicole F. Steinmetz – Case Western Reserve University – Bio-inspired nanoparticle-based reperfusion therapy
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Noah Johnson – University of Pittsburgh – Controlled delivery of sonic hedgehog morphogen for cardiac repair
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Jeffrey T. Krawiec – University of Pittsburgh – Defective smooth muscle cell recruitment by adipose-derived mesenchymal stem cells from elderly patients: A cautionary tale for autologous vascular tissue engineering
Session IV: Tissue Remodeling, Cell-based Therapies and Tissue Engineering for
Cardiovascular Disease
Co-sponsored by the North American Vascular Biology Organization (NAVBO)
Session Co-Chairs:
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Frederick Schoen, MD, PhD – Brigham and Women’s Hospital and Harvard University
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Keith March, MD, PhD – Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine
Session Invited Speakers:
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Keith March, MD, PhD – Indiana University School of Medicine – Adipose stem cells in angiogenesis, vasculogenesis and tissue repair
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Anand Ramamurthi, PhD – Cleveland Clinic – Stem cell therapy for abdominal aortic aneurysm
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Amit Patel, MD – University of Utah – Optimizing biological therapies for cardiac disease
Session Proffered Abstract Presentations:
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Benjamin R. Green – University of Pittsburgh – Phenotypic diversity of perivascular progenitor cells from human aorta
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Olga Stenina-Adognravi – Cleveland Clinic – Tissue-specific regulation of hyperglycemia-induced angiogenesis
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Stuart K. Williams – Cardiovascular Innovation Institute – 3d bioprinting of cardiovascular tissues
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Deirdre E. J. Anderson – Oregon Health & Science University – In vitro markers of endothelial hemostatic function predict ex vivo and in vivo performance of flow-conditioned endothelialized ePTFE grafts
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Robert A. Allen – University of Pittsburgh – Nerve and elastin regeneration on elastic and fast-resorbing vascular grafts
Session V: Translation, Regulatory Science and Commercialization
Co-sponsored by the Global Cardiovascular Innovation Center (GCIC)
Session Co-Chairs:
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Simon Hoerstrup, MD, PhD – University Hospital Zurich
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Ivan Vesely, PhD – ValveXchange, Inc.
Session Invited Speakers:
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Simon Hoerstrup, MD, PhD – University Hospital Zurich – Clinical translation of tissue engineered substitutes for pediatric patients (on both sides of the Atlantic) – US/EU FIM trials
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Ivan Vesely, PhD – ValveXchange, Inc. – Strategies in selecting a clinical trial site in different parts of the world
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Art Coury, PhD – Coury Consulting Services – Commercialization of regenerative products: The academic/industry partnership
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Avi Fischer, MD, FACC, FHRS – St. Jude Medical - Medical device innovation from concept to commercialization: Challenges and opportunities in the new healthcare environment
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Mark Low, Managing Director – Global Cardiovascular Innovation Center (GCIC) – New resources for translation of early stage biomedical innovations from the research laboratory to commercial development
ADDITIONAL PROGRAM HIGHLIGHTS:
Thursday Post-luncheon speaker: Roland Fasol, MD, PhD, Head of Cardiac Surgery, The Jilin Heart Hospital, Changchun, China – Challenges to start a modern heart hospital in rural China
Panel Discussion: 25 Years of Applied Cardiovascular Biology: Where have we been? Where are we going? What are our greatest opportunities?
Panel Moderator: Frederick Schoen, MD, PhD – Brigham and Women’s Hospital
Invited Panelists:
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Linda Graham, MD – Cleveland Clinic
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James Anderson, MD, PhD – Case Western Reserve University
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Alexander Clowes, MD – University of Washington
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Howard Greisler, MD – Loyola University
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Michael Wolf – Medtronic, Inc.
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D.Geoffrey Vince, PhD – Cleveland Clinic
All posters accepted for presentations will be posted throughout the meeting. However, it is the tradition of ISACB to host an interactive poster sessions at which poster authors stand with their poster and interact with meeting attendees providing the opportunity for engagement and discussion. The interactive poster session will be held at the midpoint of the meeting.
Late-Breaking Abstract Podium Presentations
Session Co-Chairs:
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Alexander Clowes, MD – University of Washington
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Gary Bowlin, PhD – University of Memphis
The following late-breaking abstracts will be presented:
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M.K. Sewell-Loftin – Vanderbilt University, Nashville, TN – Myocardial contractile forces regulate epithelial to mesencymal transformation in endocardial cells
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Joshua D. Hutcheson – Brigham and Women’s Hospital and Harvard Medical School, Boston, MA – Plaque-destabilizing microcalcifications: Novel insights into atherosclerotic plaque vulnerability
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Juan Melero-Martin – Boston Children’s Hospital, Boston, MA – Endothelial paracrine regulation of human mesenchymal stem cell engraftment
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Mohammed S. El-Kurdi – Neograft Technologies, Inc. – Effecting in-situ remodeling of saphenous vein bypass grafts using a conformal electrospun external support
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Keith Gooch – Ohio State University, Columbus, OH – Arterial levels of oxygen stimulate intimal hyperplasia in human saphenous veins via a ROS-dependent mechanism