19th BiEnnial Meeting ISACB Vienna 2024
SCIENTIFIC PROGRAM
Updated 12 Sept 2024
SATURDAY 5th October 2024
Session #1: ‘Omics Technologies in Applied Cardiovascular Biology
2:00-3:30 pm
Chairs:
Craig J. GOERGEN, Purdue University, USA
Elena AIKAWA, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
Cynthia ST. HILAIRE, University of Pittsburgh, USA
Invited talks:
Proteomics Strategies to Identify New Diagnostic and Therapeutic Targets
Manuel Mayr, Imperial College London, United Kingdom (20+3min)
Key molecular signatures of unstable atherosclerosis illuminated by multi-omics integrations from a large biobank
Ljubica Matic, Karolinska Institute, Sweden (20+3min)
Proteomics of Cardiovascular and Heart Valve Diseases: Changing Dogmas, Establishing New Concepts, and Facilitating Drug Target Discovery
Sasha A. Singh, Harvard Medical School, USA (20+3min)
Submitted abstracts:
Y chromosome linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues
Brian Aguado, University of California San Diego, USA (8+2min)
In vitro models of acute and chronic cardiac injury: characterization and differences in the cardiac troponin I and T release
Julia Milan, University of Basel, Switzerland (8+2min)
Session #2: Pre-clinical Novelties in Vascular Tissue Engineering (ISVTE session)
3:30-5:00 pm
Chairs:
Christopher BREUER, Ohio State University College of Medicine, USA
Deling KONG, Nankai University, Tianjin, China
Timothy PENNEL, University of Cape Town, South Africa
Mackenzie TURNER, Nationwide Children’s Hospital, USA
Invited talks:
Coatings for Vascular Grafts
Beat H. WALPOTH, University of Geneva, Switzerland (20+3min)
An electronic vascular graft based on cell sheet rolling technology
Xingyu JIANG, Southern University of Science and Technology China (15+2min)
Recent advances in the preclinical evaluation of completely biological vascular grafts woven from threads of Cell-Assembled extracellular Matrix (CAM)
Nicolas L’HEUREUX, Bordeaux University, France (10+2min)
Engineered vascular grafts exhibiting somatic growth in lambs
Robert TRANQUILLO, University of Minnesota, USA (10+2min)
Submitted abstracts:
A Balancing Act: Platelets as the Initiators of Both TEVG Neotissue Formation and Stenosis
Mackenzie TURNER, Nationwide Children’s Hospital, USA (8+2min)
XABG: A Restorative Polymeric Coronary Artery Bypass Conduit
Martijn COX, Xeltis BV, The Netherlands (8+2min)
Tailored Endothelialization Accelerates Remodeling of Small-diameter Vascular Grafts
Jianglin WANG, Huazhong University of Science and Technology, China (8+2min)
SUNDAY 6th October 2024
Official Welcome to the 19th Biennial ISACB Meeting
8:00-8:15am
Session #3: Dr. Allan Callow Young Investigator Award session (Rapid Fire)
8:15-9:00 am
Chairs:
Craig J. GOERGEN, Purdue University, USA
Giovanni FERRARI, Columbia University, USA
Merle KREBBER, University Medical Center Utrecht, The Netherlands
Novel Surgical Model of Thoracic Aortic Aneurysm Mediated by Vasa Vasorum Inhibition
Bryant Fisher, University of Pittsburgh, USA (5+1min)
PCSK9 inhibition promotes intraplaque angiogenesis in accelerated atherosclerosis independent of cholesterol
Vincent Sier, University of Leiden, The Netherlands (5+1min)
First long-term preclinical evaluation of a fully biological, human, woven vascular graft
Diane Potart, Bordeaux, France (5+1min)
Reverse remodeling of the left ventricle during recovery from pressure overload in a refined murine model
Elnaz Ghajar-Rahimi, Purdue University, USA (5+1min)
Assessing Growth Adaptation of the IRIS Transcatheter Pulmonary Valve for Pediatric Patients: Histopathological Analysis after Six Months
Nnaoma Agwu, University of California-Irvine, USA (5+1min)
Neurovascular hypoxia after mild traumatic brain injury in juvenile mice correlates with cardiac maladaptation in adulthood
Nicolas Hense, Aachen, Germany (5+1min)
Piezo1 expression increases under disturbed flow model of femoral atherosclerosis
Gloriani Sanchez Marrero, Atlanta, Georgia, USA (5+1min)
Elena Aikawa Trailblazer Award Lecture
Chairs:
Sara Vasconcelos, University of Toronto, Canada
Rebecca Levit, Emory University, USA (Introduction)
Introduction by Elena AIKAWA MD PhD
9:00-9:30 am
Engineering Vascular Regeneration: Perseverance and Serendipity
Ngan F. Huang, Stanford University, USA
Session #4: Cardiovascular Calcification and Inflammation
9:30-10:30 am
Chairs:
Josh Hutcheson, Florida International University, USA
Claudia Goetsch, Uniklinik RWTH Aachen, Germany
Invited talks:
New Concepts in Vascular Calcification Pathobiology and Mitigation
Cecilia Giachelli, University of Washington, USA (15+2min)
Mineralomics and Cardiovascular Calcification
Sergio Bertazzo, University College London, United Kingdom (15+2min)
Submitted abstracts:
Tissue Engineered Blood Vessels to Examine Inflammation in Cardiovascular Diseases
George Truskey, Duke University, USA (8+2min)
Prognostic Value of 18F-NaF PET/CT Imaging for Predicting 1.5-Year Progression of Vascular Calcification in Peripheral Artery Disease
Mitchel Stacy, Nationwide Children’s Hospital, USA (8+2min)
EGFR inhibition prevents CAV1-dependent calcifying extracellular vesicle biogenesis in the vasculature at different time points both in vivo and in vitro
Sophie Ashbrook, Florida International University, USA (8+2min)
Session #5: New Developments in Transplantation and Organ Preservation
11:00 am -12:30 pm
Chairs:
Julie Phillippi, University of Pittsburgh, USA
Bruno Podesser, Medical University of Vienna, Austria
David Kalfa, Columbia University, USA
Invited talks:
How to get out the ice age: temperature control systems and machine perfusion in heart transplantation
Andreas Zuckermann, Medical University of Vienna, Austria (15 +2min)
Subzero Organ Preservation - Taking Time Out of the Equation in Transplantation
Gerald Brandacher, Medical University of Innsbruck, Austria (15+2min)
Partial heart transplant and living allogenic heart valve: a clinical and translational research perspective
David Kalfa, Columbia University, USA (15+2min)
Submitted abstracts:
Mitochondrial and Metabolic Therapies for Heart Failure Based on the Regenerative Potential of the Pediatric Heart
Fatemeh Mirshafiei, University of Toronto, Canada (8+2min)
A minimal-invasive implantation of haem-scavenging microsponges protects heart against ferroptosis-induced reperfusion injury
Liwen ZHang, Zhejiang University, China (8+2min)
Long-Term Tolerance to Heart Allografts Through Selective Expansion of regulatory T-cells
Laurenz Wolner, Medical University of Vienna, Austria (8+2min)
12:30-01:45 pm
Poster sessions I-IV in parallel
Session #6: Cardiovascular Imaging
1:45-3:15 pm
Chairs:
Attila Kiss, Medical University of Vienna, Austria
Hannah Cebull, Emory University, USA
Giovanni Ferrari, Columbia University, USA
Invited Lectures:
Cardiovascular preclinical imaging: Vienna experience
Attila KISS, Medical University of Vienna, Austria (15+2min)
Neurovascular hypoxia after mild traumatic brain injury in juvenile mice correlates with cardiac maladaptation in adulthood
Pierre Sicard, INSERM Montpellier, Université de Montpellier, France (15+2min)
Submitted abstracts:
Sex-Based Machine Learning Models for Prediction of Abdominal Aortic Aneurysm Patient Outcomes
Kathrine Kerr, University of Pittsburgh, USA (8+2min)
Hemodynamics of Acute Type B Aortic Dissections with 4D Flow MRI
Hannah Cebull, Emory University, USA (8+2min)
Mechanical Behavior of the Dissected Aortic Media During Radial Extension
Selda Sherifova, Saint-Étienne School of Mines, France (8+2min)
“Attractive” Treatment for Abdominal Aortic Aneurysm Repair: Magnetic Localization of Silk-Iron Packaged Extracellular Vesicles
Ande Marini, University of Pittsburgh, USA (8+2min)
Session #7: Advanced Stage Cardiovascular Device Innovations in Biomaterials and Designs
3:45-5:45 pm
Chairs:
Michael Wolf, Medtronic, USA
Art Coury, Northeastern University, USA
Rainald Seitelberger, Uniklinikum Salzburg, Austria
Carlijn Bouten, University of Eindhoven, The Netherlands
Invited talks:
Polymers used in Commercial Valves: Past, Present, and the Future
Shrojal Desai, Edwards Lifesciences, USA (20+3min)
Update: Catering for the many: Polymeric TAVR for rheumatic heart disease
Peter Zilla, SAT, University of Cape Town, South Africa (15+2min)
Differential Tissue Response to Bioresorbable Scaffolds in the Pulmonary and Aortic Position
Carlijn Bouten, University of Eindhoven, The Netherlands (15+2min)
A Synthetic Vascular Graft Reconstructs to a Functional Vessel
Buddy Ratner, University of Washington, USA (15+2min)
Submitted abstracts:
Fish swim bladders as valve leaflets enhance the durability of transcatheter aortic valve replacement devices
Zhihong Wang, Nankai School of Medicine, China (8+2min)
Design, Development, and Fabrication of a Bioresorbable Polymeric Heart Valve Stent using 3D Printing
Arian Ehterami, University of Zurich, Switzerland (8+2min)
In vitro and in vivo testing of a novel, fully absorbable magnesium-based annuloplasty ring with inert antibacterial properties
Lukas Weber, Medical University of Vienna, Austria (8+2min)
Tribute to Professor Deon Bezuidenhout
A quarter century of collaboration and friendship
Michael F. Wolf with Introduction by Art Coury, Medtronic, USA (15 min)
Wine and Cheese Reception Opens
Panel Discussion: Heart Valve and Vascular Grafts: Novel Concepts Utilizing Polymeric Approaches; Challenges and Opportunities
5:45-6:30 pm
IWG/ISVTE Panel Q&A with all speakers
IWG Panelists: Shrojal Desai, Peter Zilla, Art COURY, Carlijn Bouten, Buddy Ratner
Session #8: Manfred Deutsch Lecture
7:00-7:45 pm
Introduction: Theodor FISCHLEIN, Klinikum Nürnberg- Paracelsus Medical University, Germany
Long-term results of clinical in-vitro endothelialization of vascular grafts
Martin GRAGBENWÖGER, Klinik Floridsdorf, Austria (10 min)
Vascular Tissue-Engineering: Pioneering Translation
Peter Zilla, SAT, University of Cape Town, South Africa
MONDAY 7th October 2024
8:30-9:00 am Business Meeting
Session #9 Engineering Tissues and Devices
9:00-10:30 am
Chairs:
Ngan HUANG, Stanford University, USA
Karl H. Schneider, Medical University of Vienna, Austria
Marjan Enayati, Medical University of Vienna, Austria
Robert Nerem Lecture
Therapeutic Vascularization Using Modular Tissue Engineering
Jan Stegemann, University of Michigan, USA (25+5min)
Invited talk:
Engineering Devices, Implants and Surgical Procedures through Additive Manufacturing and Simulation
Francesco Moscato, Medical University of Vienna, Austria (20+5min)
Submitted abstracts:
Engineering Bioelectric Threads from hiPSC-derived Cardiomyocytes to Direct Cardiac Conduction Pathways
Arvin Soepriatna, Brown University, USA (8+2min)
Protein-engineered Elastin-Like Fibers for Biomedical Textile Applications
Ikram El Maachi, Helmholtz Institute RWTH Aachen, Germany (8+2 min)
Customized in situ small caliber graft manufacturing with focused rotary jet spinning
Melanie GENERALI, University of Zurich, Switzerland (8+2min)
Session #10, Cardiac Regeneration and Pediatric Valve Transplantation
11:00 am - 12:30 pm
Chairs:
Roman Gottardi, Universitätsklinikum Freiburg, Germany
Melanie GENERALI, University of Zurich, Switzerland
Amanda Leblanc, University of Louisville, USA
Invited talks:
Heart Regeneration with Fiber-Reinforced Engineered Human Myocardium
Kareen L Coulombe, Brown University, USA (20+5min)
Partial Heart Transplantation - A New Approach to Deliver Growing Heart Valve Implants
Awais ASHFAQ, Cincinnati Children’s Hospital, USA (20+5min)
Submitted abstracts:
Bioengineering Immune Shielded Living Heart Valves for Pediatric Valve Pathologies
Marijn Peters, Eindhoven University of Technology, The Netherlands (8+2min)
Preclinical Evaluation of Cell-Assembled Extracellular Matrix Sheets for Surgical Repair of Tetralogy of Fallot
Fabien Kawecki, Inserm, University of Bordeaux, France (8+2min)
Cardiac Tissue Engineering with Metamaterials to fabricate Robust and Contractile Cardiac Tissue Patches
Lewis Jones, ETH Zurich, Switzerland (8+2min)
TUESDAY 8th October 2024
Session #11 Cardiac and Vascular Remodeling
8:30-10:30 am
Chairs:
Janice Tsui, University College London, UK
Helga Bergmeister, Medical University of Vienna, Austria
Simon Hoerstrup, University of Zurich, Switzerland
Luke Brewster, Emory University, USA
Alexander Clowes Lecture
Macrophage activation and heterogeneity in vascular diseases: a systems approach to target discovery
Masanori Aikawa, Brigham and Women’s Hospital, Harvard Medical School, USA (20+5min)
Invited talks:
Cardiovascular Biomimetics
Simon Hoerstrup, University of Zurich, Switzerland (15+2min)
The impact of metabolic alterations in myocardial Infarction: from pathophysiology to new therapeutic strategies
Gemma VILAHUR, Research Institute Sant Pau, Spain (15+2min)
Submitted abstracts:
Compliant aortic stent-grafts attenuate left ventricular mass and pulse wave velocity increases compared to stiff commercial TEVAR stent-grafts in a preclinical porcine model
Anastasia Desyatova, University of Nebraska, USA (8+2min)
Discovering the Potential for Using Stromal Vascular Fraction to Form Lymphatic Vessels
Walter Murfee, University of Florida, USA (8+2min)
Sex dependent differences in baseline extracellular matrix composition and chronic kidney disease induced aortic valve calcification in mice
Daniel Chaparro, Florida International University, USA (8+2min)
Unravelling Neointima Hyperplasia: The Role of Flow Disturbances in Endothelial Cell Activation and Matrix (Dis)organization
Mattia Manenti, Einhoven University of Technology, The Netherlands (8+2min)
Rat infection model supports improved infection resistance of restorative aXess conduits compared to ePTFE controls
Hannah Bauer, Xeltis B.V, The Netherlands (8+2min)
Spontaneous multifocal metastatic mammary tumors induce gradual development of cardiac remodeling and dysfunction in mice
Peter Pokreisz, Medical University of Vienna, Austria (8+2min)
Session # 12: New Opportunities and Challenges in Translational Innovation (Joint ISVTE session)
11:00 am -12:30 pm
Chairs:
Beat H. Walpoth, University of Geneva, Switzerland
Nicolas L'Heureux, Bordeaux University, France
Helga BERGMEISTER, Medical University of Vienna, Austria
Juan Wang, Humacyte Inc., Durham, USA
Invited talks:
Evaluation of the Performance of Tissue Engineered Vascular Grafts: Beware the Lemming
Christopher BREUER, Ohio State University College of Medicine, USA (20+2min)
Decellularized polymer-reinforced biotubes as arteriovenous grafts: Report of clinical trial
Deling KONG, Nankai University, Tianjin, China, LEADBIO Biotechnology (Hangzhou) Co., Ltd., Hangzhou, China (15+2min)
Acellular Tissue Engineered Vessels: Long-term Clinical Observations
Juan WANG, Humacyte Inc., USA (15+2min)
Clinical translation of Restorative Vascular Conduits: Update on progress and insights
Martijn COX, Xeltis BV, The Netherlands (15+2min)
Submitted abstracts
The design of a dynamic Arteriovenous Fistula, a Vascular Access only when the patient needs it
Nicolas WHITE, Leiden University Medical Center & Delft University of Technology, The Netherlands (8+2min)
Clinical Vascular Tissue Engineering under GMP Conditions
Johann MEINHART, Klinik Floridsdorf, Austria (8+2min)
Box Lunch Provided
Session # 13: Young Investigator's Symposium
1:00-4:00 pm
Successive round table discussions of early-career relevant topics. Get to meet successful ISACB members in this interactive afternoon for and by our young investigators. During each round, a central presentation will precede a plenary Q&A, providing plenty of opportunity for interaction.
Round 1: Moderator: Hannah CEBULL, Emory University, USA
Thanks a million: Grant writing tips and tricks
Craig Goergen, Purdue University, USA
Giovanni Ferrari, Columbia University, USA
Janice Tsui, University College London, UK
Round 2: Moderator: Fabien KAWECKI, Inserm, University of Bordeaux, France
Starting it up: From bench to industry
Robert Tranquillo, University of Minnesota, USA
Nicolas L'Heureux, Bordeaux University, France
Round 3: Moderator: Ande MARINI, University of Pittsburgh
The valve to success: Advice for transitioning to the next step in your career.
Brian Aguado, University of California, USA
Arvin Soepriatna, Brown University, USA
Merle Maas-Krebber, University Medical Center Utrecht, The Netherlands
4:00 pm End of meeting